Despite numerous therapeutic protein targets being genetically-validated, the challenge remains in targeting proteins with elusive allosteric sites, especially those involved in protein-protein interactions. This study addresses the gap by mapping inhibitory allosteric communication in KRAS, a challenging target. The team quantifies the impact of mutations, unveiling allosteric sites and providing a roadmap for understanding and targeting proteins involved in critical cellular pathways. This approach promises rapid identification of allosteric target sites in various proteins.