Typhoid fever is brought on by Salmonella Typhi, an invasive serovar of S. enterica subspecies enterica that infects healthy human hosts. The use of traditional antibiotics to treat typhoid fever has continuously been hampered by the advent of antibiotic-resistant bacteria. In Salmonella, extrachromosomal DNA can be acquired through horizontal gene transfer or changes in the genomic DNA can result in antibiotic resistance (AMR).