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The three Plasmodium falciparum Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual blood stage parasites and gametocytes
Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria…
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Interferon-stimulated neutrophils as a predictor of immunotherapy response
Researchers indentified interferon-stimulated, Ly6Ehi neutrophils as a blood-borne biomarker of anti-PD1 response in mice at…
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Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors
Investigators studied β-arrestins (βarrs), crucial proteins in seven transmembrane receptor (7TMR) signaling. Using cryo–electron microscopy,…
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The energetic and allosteric landscape for KRAS inhibition
Despite numerous therapeutic protein targets being genetically-validated, the challenge remains in targeting proteins with elusive…