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A global phase 3 study of serplulimab plus chemotherapy as first-line treatment for advanced squamous non-small-cell lung cancer (ASTRUM-004)
A recent study shows that First-line serplulimab plus chemotherapy improves PFS and OS and promises…
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Interferon-stimulated neutrophils as a predictor of immunotherapy response
Researchers indentified interferon-stimulated, Ly6Ehi neutrophils as a blood-borne biomarker of anti-PD1 response in mice at…
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Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors
Investigators studied β-arrestins (βarrs), crucial proteins in seven transmembrane receptor (7TMR) signaling. Using cryo–electron microscopy,…
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The energetic and allosteric landscape for KRAS inhibition
Despite numerous therapeutic protein targets being genetically-validated, the challenge remains in targeting proteins with elusive…
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Discovery of a structural class of antibiotics with explainable deep learning
Researchers urgently seek novel antibiotics amidst the ongoing antibiotic resistance crisis. This study introduces a…
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A novel antibiotic class targeting the lipopolysaccharide transporter
Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a global health threat, lacking effective treatments for over 50…