SciTrends
SciTrends is a cutting-edge platform dedicated to keeping professionals, researchers, and enthusiasts abreast of the latest developments in the scientific realm. Focused on biological, chemical, physical, life sciences, engineering, and technology, Sci-Trends serves as a centralized hub for accessing timely and relevant information from diverse scientific disciplines.
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Subversion of a family of antimicrobial proteins by Salmonella enterica
Food-borne pathogen Salmonella enterica can cause a variety of illnesses, from minor gastroenteritis to systemic infections. A broad range of host-derived antimicrobial peptides (AMPs) are anticipated to be encountered by Salmonella during nearly every stage of the infection process.
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Combination of autochthonous Lactobacillus strains and trans-Cinnamaldehyde in water reduces Salmonella Heidelberg in turkey poults
The risk of Salmonella contamination at subsequent stages of production must be reduced by reducing the colonization of the bacteria in turkeys. It is critical to put measures in place that target potential channels of transmission, such as drinking water,…
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Development of a closed-tube, calcein-based loop-mediated isothermal amplification assay to detect Salmonella spp. in raw meat samples
Salmonella spp. are among the main pathogenic bacteria that cause outbreaks globally. Foodborne infections jeopardize human health and food safety. In order to stop Salmonella outbreaks and agricultural losses, it is essential to conduct proper surveillance using prompt and economical…
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A bacteriophage cocktail can efficiently reduce five important Salmonella serotypes both on chicken skin and stainless steel
One of the most significant zoonotic infections, salmonella is primarily spread by eating food that comes from animals. One promising method for biocontrolling Salmonella on surfaces in contact with food is the use of bacteriophages.
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Antimicrobial drug resistance in Salmonella: problems and perspectives in food- and water-borne infections
Antimicrobial drug-resistant strains of Salmonella spp. are becoming common in both industrialized and developing nations. It is now widely acknowledged in industrialized nations that the majority of these viruses are zoonotic, meaning they first develop resistance in their food-animal host…
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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include…
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Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA
As you may have heard that Liquid biopsy has become an attractive tool for a range of clinical applications, including early cancer detection. Scientists investigates, “liquid biopsy shows earlier detection of cancer in patients with LFS compared with current clinical…
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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Researchers promises that AMG 509 provides a targeted immunotherapy approach to engage a patient’s T cells to kill STEAP1-expressing tumor cells and represents a new treatment option for mCRPC and potentially more broadly for prostate cancer. Immunotherapy in prostate cancer…
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First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma
A recent first-in-human phase I study shows the safety and preliminary efficacy of nemtabrutinib in patients with relapsed/refractory B-cell malignancies. These data support further exploration of nemtabrutinib in larger clinical studies.
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A new type of antibiotic targets a drug-resistant bacterium
It’s always been hard to treat the Infections caused by drug-resistant strains of the bacterium Acinetobacter baumannii in the clinic. For the same, scientists identified a new class of antibiotics with the potential to tackle these microbes.