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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans…
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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Researchers promises that AMG 509 provides a targeted immunotherapy approach to engage a patient’s T…
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First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma
A recent first-in-human phase I study shows the safety and preliminary efficacy of nemtabrutinib in…
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A new type of antibiotic targets a drug-resistant bacterium
It’s always been hard to treat the Infections caused by drug-resistant strains of the bacterium…
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Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors
Investigators studied β-arrestins (βarrs), crucial proteins in seven transmembrane receptor (7TMR) signaling. Using cryo–electron microscopy,…
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The energetic and allosteric landscape for KRAS inhibition
Despite numerous therapeutic protein targets being genetically-validated, the challenge remains in targeting proteins with elusive…
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Discovery of a structural class of antibiotics with explainable deep learning
Researchers urgently seek novel antibiotics amidst the ongoing antibiotic resistance crisis. This study introduces a…
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A novel antibiotic class targeting the lipopolysaccharide transporter
Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a global health threat, lacking effective treatments for over 50…