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Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii
Toxoplasma gondii and Cryptosporidium species are apicomplexan parasites of significant medical and veterinary importance. Although current therapeutic options…
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Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and gene expression
Toxoplasma gondii is a zoonotic apicomplexan parasite that relies on highly orchestrated gene expression programs to…
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Unraveling the complexities of ApiAP2 regulation in Plasmodium falciparum
The regulation of gene expression in Plasmodium spp., the causative agents of malaria, relies on precise transcriptional…
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The three Plasmodium falciparum Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual blood stage parasites and gametocytes
Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria…
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Interferon-stimulated neutrophils as a predictor of immunotherapy response
Researchers indentified interferon-stimulated, Ly6Ehi neutrophils as a blood-borne biomarker of anti-PD1 response in mice at…
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Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors
Investigators studied β-arrestins (βarrs), crucial proteins in seven transmembrane receptor (7TMR) signaling. Using cryo–electron microscopy,…
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The energetic and allosteric landscape for KRAS inhibition
Despite numerous therapeutic protein targets being genetically-validated, the challenge remains in targeting proteins with elusive…